AustralieFrV1, PubMed, Curation, bibRecord, 003031

Red cells from ferrochelatase-deficient erythropoietic protoporphyria patients are resistant to growth of malarial parasites.

Identifieur interne : 003031 ( PubMed/Curation ); précédent : 003030; suivant : 003032

Red cells from ferrochelatase-deficient erythropoietic protoporphyria patients are resistant to growth of malarial parasites.

Auteurs : Clare M. Smith [Australie] ; Ante Jerkovic [Australie] ; Hervé Puy [France] ; Ingrid Winship [Australie] ; Jean-Charles Deybach [France] ; Laurent Gouya [France] ; Giel Van Dooren [Australie] ; Christopher Dean Goodman [Australie] ; Angelika Sturm [Australie] ; Hana Manceau [France] ; Geoffrey Ian Mcfadden [Australie] ; Peter David ; Odile Mercereau-Puijalon ; Gaétan Burgio [Australie] ; Brendan J. Mcmorran [Australie] ; Simon J. Foote [Australie]

Source :

Blood [ 1528-0020 ] ; 2015.

RBID : pubmed:25414439

Descripteurs français

KwdFr :
- Animaux, Femelle, Ferrochelatase (antagonistes et inhibiteurs), Ferrochelatase (physiologie), Humains, Hème (métabolisme), Mâle, Paludisme à Plasmodium falciparum (), Paludisme à Plasmodium falciparum (enzymologie), Paludisme à Plasmodium falciparum (parasitologie), Phénotype, Plasmodium berghei (croissance et développement), Protoporphyrie érythropoïétique (), Protoporphyrie érythropoïétique (enzymologie), Protoporphyrie érythropoïétique (parasitologie), Protoporphyrines (pharmacologie), Souris, Souris de lignée C57BL, Érythrocytes (enzymologie), Érythrocytes (parasitologie).
MESH :
- antagonistes et inhibiteurs : Ferrochelatase.
- croissance et développement : Plasmodium berghei.
- enzymologie : Paludisme à Plasmodium falciparum, Protoporphyrie érythropoïétique, Érythrocytes.
- métabolisme : Hème.
- parasitologie : Paludisme à Plasmodium falciparum, Protoporphyrie érythropoïétique, Érythrocytes.
- pharmacologie : Protoporphyrines.
- physiologie : Ferrochelatase.
- Animaux, Femelle, Humains, Mâle, Paludisme à Plasmodium falciparum, Phénotype, Protoporphyrie érythropoïétique, Souris, Souris de lignée C57BL.

English descriptors

KwdEn :
- Animals, Erythrocytes (enzymology), Erythrocytes (parasitology), Female, Ferrochelatase (antagonists & inhibitors), Ferrochelatase (physiology), Heme (metabolism), Humans, Malaria, Falciparum (enzymology), Malaria, Falciparum (parasitology), Malaria, Falciparum (prevention & control), Male, Mice, Mice, Inbred C57BL, Phenotype, Plasmodium berghei (growth & development), Protoporphyria, Erythropoietic (enzymology), Protoporphyria, Erythropoietic (parasitology), Protoporphyria, Erythropoietic (prevention & control), Protoporphyrins (pharmacology).
MESH :
- chemical , antagonists & inhibitors : Ferrochelatase.
- enzymology : Erythrocytes, Malaria, Falciparum, Protoporphyria, Erythropoietic.
- growth & development : Plasmodium berghei.
- chemical , metabolism : Heme.
- parasitology : Erythrocytes, Malaria, Falciparum, Protoporphyria, Erythropoietic.
- chemical , pharmacology : Protoporphyrins.
- chemical , physiology : Ferrochelatase.
- prevention & control : Malaria, Falciparum, Protoporphyria, Erythropoietic.
- Animals, Female, Humans, Male, Mice, Mice, Inbred C57BL, Phenotype.

Abstract

Many red cell polymorphisms are a result of selective pressure by the malarial parasite. Here, we add another red cell disease to the panoply of erythrocytic changes that give rise to resistance to malaria. Erythrocytes from individuals with erythropoietic protoporphyria (EPP) have low levels of the final enzyme in the heme biosynthetic pathway, ferrochelatase. Cells from these patients are resistant to the growth of Plasmodium falciparum malarial parasites. This phenomenon is due to the absence of ferrochelatase and not an accumulation of substrate, as demonstrated by the normal growth of P falciparum parasites in the EPP phenocopy, X-linked dominant protoporphyria, which has elevated substrate, and normal ferrochelatase levels. This observation was replicated in a mouse strain with a hypomorphic mutation in the murine ferrochelatase gene. The parasite enzyme is not essential for parasite growth as Plasmodium berghei parasites carrying a complete deletion of the ferrochelatase gene grow normally in erythrocytes, which confirms previous studies. That ferrochelatase is essential to parasite growth was confirmed by showing that inhibition of ferrochelatase using the specific competitive inhibitor, N-methylprotoporphyrin, produced a potent growth inhibition effect against cultures of P falciparum. This raises the possibility of targeting human ferrochelatase in a host-directed antimalarial strategy.

DOI: 10.1182/blood-2014-04-567149
PubMed: 25414439

Links toward previous steps (curation, corpus...)

to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :003127

Links to Exploration step

pubmed:25414439

Curation

No country items

Peter David

<affiliation><nlm:affiliation>Institut Pasteur, Unité d'Immunologie Moléculaire des Parasites, Centre Nationale de la Recherche Scientifique, Unite de Recherche Associé 2581, Paris, France; and.</nlm:affiliation>
<wicri:noCountry code="subField">France; and</wicri:noCountry>
</affiliation>

Odile Mercereau-Puijalon

<affiliation><nlm:affiliation>Institut Pasteur, Unité d'Immunologie Moléculaire des Parasites, Centre Nationale de la Recherche Scientifique, Unite de Recherche Associé 2581, Paris, France; and.</nlm:affiliation>
<wicri:noCountry code="subField">France; and</wicri:noCountry>
</affiliation>

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Red cells from ferrochelatase-deficient erythropoietic protoporphyria patients are resistant to growth of malarial parasites.</title>
<author><name sortKey="Smith, Clare M" sort="Smith, Clare M" uniqKey="Smith C" first="Clare M" last="Smith">Clare M. Smith</name>
<affiliation wicri:level="1"><nlm:affiliation>Menzies Research Institute Tasmania and School of Medicine, University of Tasmania, Hobart, TAS, Australia;</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Menzies Research Institute Tasmania and School of Medicine, University of Tasmania, Hobart, TAS</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Jerkovic, Ante" sort="Jerkovic, Ante" uniqKey="Jerkovic A" first="Ante" last="Jerkovic">Ante Jerkovic</name>
<affiliation wicri:level="1"><nlm:affiliation>Australian School of Advanced Medicine, Macquarie University, North Ryde, NSW, Australia;</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Australian School of Advanced Medicine, Macquarie University, North Ryde, NSW</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Puy, Herve" sort="Puy, Herve" uniqKey="Puy H" first="Hervé" last="Puy">Hervé Puy</name>
<affiliation wicri:level="1"><nlm:affiliation>Centre Français des Porphyries, Hôpital Louis Mourier, Assistance Publique-Hôpitaux de Paris, Colombes, France; Centre de Recherche sur l'Inflammation, INSERM U1149, Paris, France; Groupe d'Excellence, Pôle de Recherche et d'Enseignement Supérieur, Sorbonne Paris-Cité, Paris, France;</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre Français des Porphyries, Hôpital Louis Mourier, Assistance Publique-Hôpitaux de Paris, Colombes, France; Centre de Recherche sur l'Inflammation, INSERM U1149, Paris, France; Groupe d'Excellence, Pôle de Recherche et d'Enseignement Supérieur, Sorbonne Paris-Cité, Paris</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Winship, Ingrid" sort="Winship, Ingrid" uniqKey="Winship I" first="Ingrid" last="Winship">Ingrid Winship</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, University of Melbourne, Melbourne, VIC, Australia; Office of Research, Royal Melbourne Hospital, Parkville, VIC, Australia;</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Medicine, University of Melbourne, Melbourne, VIC, Australia; Office of Research, Royal Melbourne Hospital, Parkville, VIC</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Deybach, Jean Charles" sort="Deybach, Jean Charles" uniqKey="Deybach J" first="Jean-Charles" last="Deybach">Jean-Charles Deybach</name>
<affiliation wicri:level="1"><nlm:affiliation>Centre Français des Porphyries, Hôpital Louis Mourier, Assistance Publique-Hôpitaux de Paris, Colombes, France; Centre de Recherche sur l'Inflammation, INSERM U1149, Paris, France;</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre Français des Porphyries, Hôpital Louis Mourier, Assistance Publique-Hôpitaux de Paris, Colombes, France; Centre de Recherche sur l'Inflammation, INSERM U1149, Paris</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Gouya, Laurent" sort="Gouya, Laurent" uniqKey="Gouya L" first="Laurent" last="Gouya">Laurent Gouya</name>
<affiliation wicri:level="1"><nlm:affiliation>Centre de Recherche sur l'Inflammation, INSERM U1149, Paris, France; Groupe d'Excellence, Pôle de Recherche et d'Enseignement Supérieur, Sorbonne Paris-Cité, Paris, France;</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre de Recherche sur l'Inflammation, INSERM U1149, Paris, France; Groupe d'Excellence, Pôle de Recherche et d'Enseignement Supérieur, Sorbonne Paris-Cité, Paris</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Van Dooren, Giel" sort="Van Dooren, Giel" uniqKey="Van Dooren G" first="Giel" last="Van Dooren">Giel Van Dooren</name>
<affiliation wicri:level="1"><nlm:affiliation>Research School of Biology, Australian National University, Canberra, ACT, Australia;</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Research School of Biology, Australian National University, Canberra, ACT</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Goodman, Christopher Dean" sort="Goodman, Christopher Dean" uniqKey="Goodman C" first="Christopher Dean" last="Goodman">Christopher Dean Goodman</name>
<affiliation wicri:level="1"><nlm:affiliation>School of Botany, University of Melbourne, Parkville, VIC, Australia;</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>School of Botany, University of Melbourne, Parkville, VIC</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Sturm, Angelika" sort="Sturm, Angelika" uniqKey="Sturm A" first="Angelika" last="Sturm">Angelika Sturm</name>
<affiliation wicri:level="1"><nlm:affiliation>School of Botany, University of Melbourne, Parkville, VIC, Australia;</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>School of Botany, University of Melbourne, Parkville, VIC</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Manceau, Hana" sort="Manceau, Hana" uniqKey="Manceau H" first="Hana" last="Manceau">Hana Manceau</name>
<affiliation wicri:level="1"><nlm:affiliation>Centre Français des Porphyries, Hôpital Louis Mourier, Assistance Publique-Hôpitaux de Paris, Colombes, France; Centre de Recherche sur l'Inflammation, INSERM U1149, Paris, France;</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre Français des Porphyries, Hôpital Louis Mourier, Assistance Publique-Hôpitaux de Paris, Colombes, France; Centre de Recherche sur l'Inflammation, INSERM U1149, Paris</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mcfadden, Geoffrey Ian" sort="Mcfadden, Geoffrey Ian" uniqKey="Mcfadden G" first="Geoffrey Ian" last="Mcfadden">Geoffrey Ian Mcfadden</name>
<affiliation wicri:level="1"><nlm:affiliation>School of Botany, University of Melbourne, Parkville, VIC, Australia;</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>School of Botany, University of Melbourne, Parkville, VIC</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="David, Peter" sort="David, Peter" uniqKey="David P" first="Peter" last="David">Peter David</name>
<affiliation><nlm:affiliation>Institut Pasteur, Unité d'Immunologie Moléculaire des Parasites, Centre Nationale de la Recherche Scientifique, Unite de Recherche Associé 2581, Paris, France; and.</nlm:affiliation>
<wicri:noCountry code="subField">France; and</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Mercereau Puijalon, Odile" sort="Mercereau Puijalon, Odile" uniqKey="Mercereau Puijalon O" first="Odile" last="Mercereau-Puijalon">Odile Mercereau-Puijalon</name>
<affiliation><nlm:affiliation>Institut Pasteur, Unité d'Immunologie Moléculaire des Parasites, Centre Nationale de la Recherche Scientifique, Unite de Recherche Associé 2581, Paris, France; and.</nlm:affiliation>
<wicri:noCountry code="subField">France; and</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Burgio, Gaetan" sort="Burgio, Gaetan" uniqKey="Burgio G" first="Gaétan" last="Burgio">Gaétan Burgio</name>
<affiliation wicri:level="1"><nlm:affiliation>Australian School of Advanced Medicine, Macquarie University, North Ryde, NSW, Australia;</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Australian School of Advanced Medicine, Macquarie University, North Ryde, NSW</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mcmorran, Brendan J" sort="Mcmorran, Brendan J" uniqKey="Mcmorran B" first="Brendan J" last="Mcmorran">Brendan J. Mcmorran</name>
<affiliation wicri:level="1"><nlm:affiliation>Australian School of Advanced Medicine, Macquarie University, North Ryde, NSW, Australia;</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Australian School of Advanced Medicine, Macquarie University, North Ryde, NSW</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Foote, Simon J" sort="Foote, Simon J" uniqKey="Foote S" first="Simon J" last="Foote">Simon J. Foote</name>
<affiliation wicri:level="1"><nlm:affiliation>Australian School of Advanced Medicine, Macquarie University, North Ryde, NSW, Australia; The John Curtin School of Medical Research, Australian National University, Canberra, ACT, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Australian School of Advanced Medicine, Macquarie University, North Ryde, NSW, Australia; The John Curtin School of Medical Research, Australian National University, Canberra, ACT</wicri:regionArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2015">2015</date>
<idno type="RBID">pubmed:25414439</idno>
<idno type="pmid">25414439</idno>
<idno type="doi">10.1182/blood-2014-04-567149</idno>
<idno type="wicri:Area/PubMed/Corpus">003127</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003127</idno>
<idno type="wicri:Area/PubMed/Curation">003031</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">003031</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Red cells from ferrochelatase-deficient erythropoietic protoporphyria patients are resistant to growth of malarial parasites.</title>
<author><name sortKey="Smith, Clare M" sort="Smith, Clare M" uniqKey="Smith C" first="Clare M" last="Smith">Clare M. Smith</name>
<affiliation wicri:level="1"><nlm:affiliation>Menzies Research Institute Tasmania and School of Medicine, University of Tasmania, Hobart, TAS, Australia;</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Menzies Research Institute Tasmania and School of Medicine, University of Tasmania, Hobart, TAS</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Jerkovic, Ante" sort="Jerkovic, Ante" uniqKey="Jerkovic A" first="Ante" last="Jerkovic">Ante Jerkovic</name>
<affiliation wicri:level="1"><nlm:affiliation>Australian School of Advanced Medicine, Macquarie University, North Ryde, NSW, Australia;</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Australian School of Advanced Medicine, Macquarie University, North Ryde, NSW</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Puy, Herve" sort="Puy, Herve" uniqKey="Puy H" first="Hervé" last="Puy">Hervé Puy</name>
<affiliation wicri:level="1"><nlm:affiliation>Centre Français des Porphyries, Hôpital Louis Mourier, Assistance Publique-Hôpitaux de Paris, Colombes, France; Centre de Recherche sur l'Inflammation, INSERM U1149, Paris, France; Groupe d'Excellence, Pôle de Recherche et d'Enseignement Supérieur, Sorbonne Paris-Cité, Paris, France;</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre Français des Porphyries, Hôpital Louis Mourier, Assistance Publique-Hôpitaux de Paris, Colombes, France; Centre de Recherche sur l'Inflammation, INSERM U1149, Paris, France; Groupe d'Excellence, Pôle de Recherche et d'Enseignement Supérieur, Sorbonne Paris-Cité, Paris</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Winship, Ingrid" sort="Winship, Ingrid" uniqKey="Winship I" first="Ingrid" last="Winship">Ingrid Winship</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, University of Melbourne, Melbourne, VIC, Australia; Office of Research, Royal Melbourne Hospital, Parkville, VIC, Australia;</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Medicine, University of Melbourne, Melbourne, VIC, Australia; Office of Research, Royal Melbourne Hospital, Parkville, VIC</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Deybach, Jean Charles" sort="Deybach, Jean Charles" uniqKey="Deybach J" first="Jean-Charles" last="Deybach">Jean-Charles Deybach</name>
<affiliation wicri:level="1"><nlm:affiliation>Centre Français des Porphyries, Hôpital Louis Mourier, Assistance Publique-Hôpitaux de Paris, Colombes, France; Centre de Recherche sur l'Inflammation, INSERM U1149, Paris, France;</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre Français des Porphyries, Hôpital Louis Mourier, Assistance Publique-Hôpitaux de Paris, Colombes, France; Centre de Recherche sur l'Inflammation, INSERM U1149, Paris</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Gouya, Laurent" sort="Gouya, Laurent" uniqKey="Gouya L" first="Laurent" last="Gouya">Laurent Gouya</name>
<affiliation wicri:level="1"><nlm:affiliation>Centre de Recherche sur l'Inflammation, INSERM U1149, Paris, France; Groupe d'Excellence, Pôle de Recherche et d'Enseignement Supérieur, Sorbonne Paris-Cité, Paris, France;</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre de Recherche sur l'Inflammation, INSERM U1149, Paris, France; Groupe d'Excellence, Pôle de Recherche et d'Enseignement Supérieur, Sorbonne Paris-Cité, Paris</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Van Dooren, Giel" sort="Van Dooren, Giel" uniqKey="Van Dooren G" first="Giel" last="Van Dooren">Giel Van Dooren</name>
<affiliation wicri:level="1"><nlm:affiliation>Research School of Biology, Australian National University, Canberra, ACT, Australia;</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Research School of Biology, Australian National University, Canberra, ACT</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Goodman, Christopher Dean" sort="Goodman, Christopher Dean" uniqKey="Goodman C" first="Christopher Dean" last="Goodman">Christopher Dean Goodman</name>
<affiliation wicri:level="1"><nlm:affiliation>School of Botany, University of Melbourne, Parkville, VIC, Australia;</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>School of Botany, University of Melbourne, Parkville, VIC</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Sturm, Angelika" sort="Sturm, Angelika" uniqKey="Sturm A" first="Angelika" last="Sturm">Angelika Sturm</name>
<affiliation wicri:level="1"><nlm:affiliation>School of Botany, University of Melbourne, Parkville, VIC, Australia;</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>School of Botany, University of Melbourne, Parkville, VIC</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Manceau, Hana" sort="Manceau, Hana" uniqKey="Manceau H" first="Hana" last="Manceau">Hana Manceau</name>
<affiliation wicri:level="1"><nlm:affiliation>Centre Français des Porphyries, Hôpital Louis Mourier, Assistance Publique-Hôpitaux de Paris, Colombes, France; Centre de Recherche sur l'Inflammation, INSERM U1149, Paris, France;</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre Français des Porphyries, Hôpital Louis Mourier, Assistance Publique-Hôpitaux de Paris, Colombes, France; Centre de Recherche sur l'Inflammation, INSERM U1149, Paris</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mcfadden, Geoffrey Ian" sort="Mcfadden, Geoffrey Ian" uniqKey="Mcfadden G" first="Geoffrey Ian" last="Mcfadden">Geoffrey Ian Mcfadden</name>
<affiliation wicri:level="1"><nlm:affiliation>School of Botany, University of Melbourne, Parkville, VIC, Australia;</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>School of Botany, University of Melbourne, Parkville, VIC</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="David, Peter" sort="David, Peter" uniqKey="David P" first="Peter" last="David">Peter David</name>
<affiliation><nlm:affiliation>Institut Pasteur, Unité d'Immunologie Moléculaire des Parasites, Centre Nationale de la Recherche Scientifique, Unite de Recherche Associé 2581, Paris, France; and.</nlm:affiliation>
<wicri:noCountry code="subField">France; and</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Mercereau Puijalon, Odile" sort="Mercereau Puijalon, Odile" uniqKey="Mercereau Puijalon O" first="Odile" last="Mercereau-Puijalon">Odile Mercereau-Puijalon</name>
<affiliation><nlm:affiliation>Institut Pasteur, Unité d'Immunologie Moléculaire des Parasites, Centre Nationale de la Recherche Scientifique, Unite de Recherche Associé 2581, Paris, France; and.</nlm:affiliation>
<wicri:noCountry code="subField">France; and</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Burgio, Gaetan" sort="Burgio, Gaetan" uniqKey="Burgio G" first="Gaétan" last="Burgio">Gaétan Burgio</name>
<affiliation wicri:level="1"><nlm:affiliation>Australian School of Advanced Medicine, Macquarie University, North Ryde, NSW, Australia;</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Australian School of Advanced Medicine, Macquarie University, North Ryde, NSW</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mcmorran, Brendan J" sort="Mcmorran, Brendan J" uniqKey="Mcmorran B" first="Brendan J" last="Mcmorran">Brendan J. Mcmorran</name>
<affiliation wicri:level="1"><nlm:affiliation>Australian School of Advanced Medicine, Macquarie University, North Ryde, NSW, Australia;</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Australian School of Advanced Medicine, Macquarie University, North Ryde, NSW</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Foote, Simon J" sort="Foote, Simon J" uniqKey="Foote S" first="Simon J" last="Foote">Simon J. Foote</name>
<affiliation wicri:level="1"><nlm:affiliation>Australian School of Advanced Medicine, Macquarie University, North Ryde, NSW, Australia; The John Curtin School of Medical Research, Australian National University, Canberra, ACT, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Australian School of Advanced Medicine, Macquarie University, North Ryde, NSW, Australia; The John Curtin School of Medical Research, Australian National University, Canberra, ACT</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Blood</title>
<idno type="eISSN">1528-0020</idno>
<imprint><date when="2015" type="published">2015</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Erythrocytes (enzymology)</term>
<term>Erythrocytes (parasitology)</term>
<term>Female</term>
<term>Ferrochelatase (antagonists & inhibitors)</term>
<term>Ferrochelatase (physiology)</term>
<term>Heme (metabolism)</term>
<term>Humans</term>
<term>Malaria, Falciparum (enzymology)</term>
<term>Malaria, Falciparum (parasitology)</term>
<term>Malaria, Falciparum (prevention & control)</term>
<term>Male</term>
<term>Mice</term>
<term>Mice, Inbred C57BL</term>
<term>Phenotype</term>
<term>Plasmodium berghei (growth & development)</term>
<term>Protoporphyria, Erythropoietic (enzymology)</term>
<term>Protoporphyria, Erythropoietic (parasitology)</term>
<term>Protoporphyria, Erythropoietic (prevention & control)</term>
<term>Protoporphyrins (pharmacology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Femelle</term>
<term>Ferrochelatase (antagonistes et inhibiteurs)</term>
<term>Ferrochelatase (physiologie)</term>
<term>Humains</term>
<term>Hème (métabolisme)</term>
<term>Mâle</term>
<term>Paludisme à Plasmodium falciparum ()</term>
<term>Paludisme à Plasmodium falciparum (enzymologie)</term>
<term>Paludisme à Plasmodium falciparum (parasitologie)</term>
<term>Phénotype</term>
<term>Plasmodium berghei (croissance et développement)</term>
<term>Protoporphyrie érythropoïétique ()</term>
<term>Protoporphyrie érythropoïétique (enzymologie)</term>
<term>Protoporphyrie érythropoïétique (parasitologie)</term>
<term>Protoporphyrines (pharmacologie)</term>
<term>Souris</term>
<term>Souris de lignée C57BL</term>
<term>Érythrocytes (enzymologie)</term>
<term>Érythrocytes (parasitologie)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Ferrochelatase</term>
</keywords>
<keywords scheme="MESH" qualifier="antagonistes et inhibiteurs" xml:lang="fr"><term>Ferrochelatase</term>
</keywords>
<keywords scheme="MESH" qualifier="croissance et développement" xml:lang="fr"><term>Plasmodium berghei</term>
</keywords>
<keywords scheme="MESH" qualifier="enzymologie" xml:lang="fr"><term>Paludisme à Plasmodium falciparum</term>
<term>Protoporphyrie érythropoïétique</term>
<term>Érythrocytes</term>
</keywords>
<keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Erythrocytes</term>
<term>Malaria, Falciparum</term>
<term>Protoporphyria, Erythropoietic</term>
</keywords>
<keywords scheme="MESH" qualifier="growth & development" xml:lang="en"><term>Plasmodium berghei</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Heme</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Hème</term>
</keywords>
<keywords scheme="MESH" qualifier="parasitologie" xml:lang="fr"><term>Paludisme à Plasmodium falciparum</term>
<term>Protoporphyrie érythropoïétique</term>
<term>Érythrocytes</term>
</keywords>
<keywords scheme="MESH" qualifier="parasitology" xml:lang="en"><term>Erythrocytes</term>
<term>Malaria, Falciparum</term>
<term>Protoporphyria, Erythropoietic</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Protoporphyrines</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Protoporphyrins</term>
</keywords>
<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Ferrochelatase</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en"><term>Ferrochelatase</term>
</keywords>
<keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Malaria, Falciparum</term>
<term>Protoporphyria, Erythropoietic</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Mice</term>
<term>Mice, Inbred C57BL</term>
<term>Phenotype</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Femelle</term>
<term>Humains</term>
<term>Mâle</term>
<term>Paludisme à Plasmodium falciparum</term>
<term>Phénotype</term>
<term>Protoporphyrie érythropoïétique</term>
<term>Souris</term>
<term>Souris de lignée C57BL</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Many red cell polymorphisms are a result of selective pressure by the malarial parasite. Here, we add another red cell disease to the panoply of erythrocytic changes that give rise to resistance to malaria. Erythrocytes from individuals with erythropoietic protoporphyria (EPP) have low levels of the final enzyme in the heme biosynthetic pathway, ferrochelatase. Cells from these patients are resistant to the growth of Plasmodium falciparum malarial parasites. This phenomenon is due to the absence of ferrochelatase and not an accumulation of substrate, as demonstrated by the normal growth of P falciparum parasites in the EPP phenocopy, X-linked dominant protoporphyria, which has elevated substrate, and normal ferrochelatase levels. This observation was replicated in a mouse strain with a hypomorphic mutation in the murine ferrochelatase gene. The parasite enzyme is not essential for parasite growth as Plasmodium berghei parasites carrying a complete deletion of the ferrochelatase gene grow normally in erythrocytes, which confirms previous studies. That ferrochelatase is essential to parasite growth was confirmed by showing that inhibition of ferrochelatase using the specific competitive inhibitor, N-methylprotoporphyrin, produced a potent growth inhibition effect against cultures of P falciparum. This raises the possibility of targeting human ferrochelatase in a host-directed antimalarial strategy.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25414439</PMID>
<DateCreated><Year>2015</Year>
<Month>01</Month>
<Day>16</Day>
</DateCreated>
<DateCompleted><Year>2015</Year>
<Month>03</Month>
<Day>12</Day>
</DateCompleted>
<DateRevised><Year>2015</Year>
<Month>10</Month>
<Day>28</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1528-0020</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>125</Volume>
<Issue>3</Issue>
<PubDate><Year>2015</Year>
<Month>Jan</Month>
<Day>15</Day>
</PubDate>
</JournalIssue>
<Title>Blood</Title>
<ISOAbbreviation>Blood</ISOAbbreviation>
</Journal>
<ArticleTitle>Red cells from ferrochelatase-deficient erythropoietic protoporphyria patients are resistant to growth of malarial parasites.</ArticleTitle>
<Pagination><MedlinePgn>534-41</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1182/blood-2014-04-567149</ELocationID>
<Abstract><AbstractText>Many red cell polymorphisms are a result of selective pressure by the malarial parasite. Here, we add another red cell disease to the panoply of erythrocytic changes that give rise to resistance to malaria. Erythrocytes from individuals with erythropoietic protoporphyria (EPP) have low levels of the final enzyme in the heme biosynthetic pathway, ferrochelatase. Cells from these patients are resistant to the growth of Plasmodium falciparum malarial parasites. This phenomenon is due to the absence of ferrochelatase and not an accumulation of substrate, as demonstrated by the normal growth of P falciparum parasites in the EPP phenocopy, X-linked dominant protoporphyria, which has elevated substrate, and normal ferrochelatase levels. This observation was replicated in a mouse strain with a hypomorphic mutation in the murine ferrochelatase gene. The parasite enzyme is not essential for parasite growth as Plasmodium berghei parasites carrying a complete deletion of the ferrochelatase gene grow normally in erythrocytes, which confirms previous studies. That ferrochelatase is essential to parasite growth was confirmed by showing that inhibition of ferrochelatase using the specific competitive inhibitor, N-methylprotoporphyrin, produced a potent growth inhibition effect against cultures of P falciparum. This raises the possibility of targeting human ferrochelatase in a host-directed antimalarial strategy.</AbstractText>
<CopyrightInformation>© 2015 by The American Society of Hematology.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Smith</LastName>
<ForeName>Clare M</ForeName>
<Initials>CM</Initials>
<AffiliationInfo><Affiliation>Menzies Research Institute Tasmania and School of Medicine, University of Tasmania, Hobart, TAS, Australia;</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Jerkovic</LastName>
<ForeName>Ante</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Australian School of Advanced Medicine, Macquarie University, North Ryde, NSW, Australia;</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Puy</LastName>
<ForeName>Hervé</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>Centre Français des Porphyries, Hôpital Louis Mourier, Assistance Publique-Hôpitaux de Paris, Colombes, France; Centre de Recherche sur l'Inflammation, INSERM U1149, Paris, France; Groupe d'Excellence, Pôle de Recherche et d'Enseignement Supérieur, Sorbonne Paris-Cité, Paris, France;</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Winship</LastName>
<ForeName>Ingrid</ForeName>
<Initials>I</Initials>
<AffiliationInfo><Affiliation>Department of Medicine, University of Melbourne, Melbourne, VIC, Australia; Office of Research, Royal Melbourne Hospital, Parkville, VIC, Australia;</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Deybach</LastName>
<ForeName>Jean-Charles</ForeName>
<Initials>JC</Initials>
<AffiliationInfo><Affiliation>Centre Français des Porphyries, Hôpital Louis Mourier, Assistance Publique-Hôpitaux de Paris, Colombes, France; Centre de Recherche sur l'Inflammation, INSERM U1149, Paris, France;</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Gouya</LastName>
<ForeName>Laurent</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Centre de Recherche sur l'Inflammation, INSERM U1149, Paris, France; Groupe d'Excellence, Pôle de Recherche et d'Enseignement Supérieur, Sorbonne Paris-Cité, Paris, France;</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>van Dooren</LastName>
<ForeName>Giel</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>Research School of Biology, Australian National University, Canberra, ACT, Australia;</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Goodman</LastName>
<ForeName>Christopher Dean</ForeName>
<Initials>CD</Initials>
<AffiliationInfo><Affiliation>School of Botany, University of Melbourne, Parkville, VIC, Australia;</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Sturm</LastName>
<ForeName>Angelika</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>School of Botany, University of Melbourne, Parkville, VIC, Australia;</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Manceau</LastName>
<ForeName>Hana</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>Centre Français des Porphyries, Hôpital Louis Mourier, Assistance Publique-Hôpitaux de Paris, Colombes, France; Centre de Recherche sur l'Inflammation, INSERM U1149, Paris, France;</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>McFadden</LastName>
<ForeName>Geoffrey Ian</ForeName>
<Initials>GI</Initials>
<AffiliationInfo><Affiliation>School of Botany, University of Melbourne, Parkville, VIC, Australia;</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>David</LastName>
<ForeName>Peter</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Institut Pasteur, Unité d'Immunologie Moléculaire des Parasites, Centre Nationale de la Recherche Scientifique, Unite de Recherche Associé 2581, Paris, France; and.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Mercereau-Puijalon</LastName>
<ForeName>Odile</ForeName>
<Initials>O</Initials>
<AffiliationInfo><Affiliation>Institut Pasteur, Unité d'Immunologie Moléculaire des Parasites, Centre Nationale de la Recherche Scientifique, Unite de Recherche Associé 2581, Paris, France; and.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Burgio</LastName>
<ForeName>Gaétan</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>Australian School of Advanced Medicine, Macquarie University, North Ryde, NSW, Australia;</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>McMorran</LastName>
<ForeName>Brendan J</ForeName>
<Initials>BJ</Initials>
<AffiliationInfo><Affiliation>Australian School of Advanced Medicine, Macquarie University, North Ryde, NSW, Australia;</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Foote</LastName>
<ForeName>Simon J</ForeName>
<Initials>SJ</Initials>
<AffiliationInfo><Affiliation>Australian School of Advanced Medicine, Macquarie University, North Ryde, NSW, Australia; The John Curtin School of Medical Research, Australian National University, Canberra, ACT, Australia.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2014</Year>
<Month>11</Month>
<Day>20</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>Blood</MedlineTA>
<NlmUniqueID>7603509</NlmUniqueID>
<ISSNLinking>0006-4971</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D011524">Protoporphyrins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>42VZT0U6YR</RegistryNumber>
<NameOfSubstance UI="D006418">Heme</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>79236-56-9</RegistryNumber>
<NameOfSubstance UI="C028842">N-methylprotoporphyrin IX</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 4.99.1.1</RegistryNumber>
<NameOfSubstance UI="D005294">Ferrochelatase</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>AIM</CitationSubset>
<CitationSubset>IM</CitationSubset>
<CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Cell Microbiol. 2011 Jun;13(6):836-45</RefSource>
<PMID Version="1">21371233</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Blood Transfus. 2010 Jun;8 Suppl 3:s126-39</RefSource>
<PMID Version="1">20606743</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>PLoS Biol. 2011 Aug;9(8):e1001138</RefSource>
<PMID Version="1">21912516</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Biomed Chromatogr. 2012 Jun;26(6):714-9</RefSource>
<PMID Version="1">22031323</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Antioxid Redox Signal. 2012 Aug 15;17(4):634-56</RefSource>
<PMID Version="1">22320355</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Curr Pharm Des. 2013;19(2):290-9</RefSource>
<PMID Version="1">22973886</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Hum Mol Genet. 2013 Apr 1;22(7):1280-8</RefSource>
<PMID Version="1">23263862</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>PLoS Pathog. 2013;9(8):e1003522</RefSource>
<PMID Version="1">23935500</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Biochem Biophys Res Commun. 2000 Feb 24;268(3):665-8</RefSource>
<PMID Version="1">10679261</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Nat Med. 2000 Aug;6(8):898-903</RefSource>
<PMID Version="1">10932227</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Clin Pathol. 2001 Jul;54(7):500-7</RefSource>
<PMID Version="1">11429419</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Nat Genet. 2002 Jan;30(1):27-8</RefSource>
<PMID Version="1">11753383</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Curr Genet. 2003 Feb;42(5):292-300</RefSource>
<PMID Version="1">12589469</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Biol Chem. 2004 Feb 20;279(8):6934-42</RefSource>
<PMID Version="1">14638682</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Pharmacogenomics J. 2004;4(3):141-2</RefSource>
<PMID Version="1">15037860</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Science. 1976 Aug 20;193(4254):673-5</RefSource>
<PMID Version="1">781840</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Protozool. 1983 May;30(2):367-70</RefSource>
<PMID Version="1">6313915</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Biomed Chromatogr. 1987;2(4):164-8</RefSource>
<PMID Version="1">3507230</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Blood. 1989 Sep;74(4):1213-21</RefSource>
<PMID Version="1">2669996</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Biochem Biophys Res Commun. 1992 Sep 16;187(2):744-50</RefSource>
<PMID Version="1">1356337</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Proc Assoc Am Physicians. 1999 Jul-Aug;111(4):272-7</RefSource>
<PMID Version="1">10417733</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Biochem J. 2004 Dec 1;384(Pt 2):429-36</RefSource>
<PMID Version="1">15307818</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Science. 2005 Jan 7;307(5706):82-6</RefSource>
<PMID Version="1">15637271</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Cell Microbiol. 2005 Jun;7(6):753-63</RefSource>
<PMID Version="1">15888079</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Am J Physiol Gastrointest Liver Physiol. 2005 Jun;288(6):G1208-16</RefSource>
<PMID Version="1">15677551</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Mol Biochem Parasitol. 2006 Jan;145(1):60-70</RefSource>
<PMID Version="1">16242190</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Am J Hum Genet. 2006 Jan;78(1):2-14</RefSource>
<PMID Version="1">16385445</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Blood. 2006 Aug 1;108(3):791-801</RefSource>
<PMID Version="1">16861337</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Curr Opin Microbiol. 2006 Aug;9(4):388-94</RefSource>
<PMID Version="1">16815736</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Biochem J. 2006 Oct 1;399(1):21-8</RefSource>
<PMID Version="1">16792525</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Blood. 2007 Jan 15;109(2):811-8</RefSource>
<PMID Version="1">17003376</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Cytometry A. 2007 May;71(5):297-307</RefSource>
<PMID Version="1">17279569</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Blood. 2007 Dec 1;110(12):4108-10</RefSource>
<PMID Version="1">17804693</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Malar J. 2008;7:45</RefSource>
<PMID Version="1">18321384</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Mol Cell Proteomics. 2008 Jul;7(7):1317-30</RefSource>
<PMID Version="1">18344233</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Am J Hum Genet. 2008 Sep;83(3):408-14</RefSource>
<PMID Version="1">18760763</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Int J Parasitol. 2009 Apr;39(5):559-68</RefSource>
<PMID Version="1">19041871</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 2009 Aug 11;106(32):13323-8</RefSource>
<PMID Version="1">19666612</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Orphanet J Rare Dis. 2009;4:19</RefSource>
<PMID Version="1">19744342</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Lancet. 2010 Mar 13;375(9718):924-37</RefSource>
<PMID Version="1">20226990</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Blood. 2011 Aug 11;118(6):1443-51</RefSource>
<PMID Version="1">21653323</PMID>
</CommentsCorrections>
</CommentsCorrectionsList>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004912" MajorTopicYN="N">Erythrocytes</DescriptorName>
<QualifierName UI="Q000201" MajorTopicYN="N">enzymology</QualifierName>
<QualifierName UI="Q000469" MajorTopicYN="Y">parasitology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005294" MajorTopicYN="N">Ferrochelatase</DescriptorName>
<QualifierName UI="Q000037" MajorTopicYN="N">antagonists & inhibitors</QualifierName>
<QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006418" MajorTopicYN="N">Heme</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016778" MajorTopicYN="N">Malaria, Falciparum</DescriptorName>
<QualifierName UI="Q000201" MajorTopicYN="N">enzymology</QualifierName>
<QualifierName UI="Q000469" MajorTopicYN="N">parasitology</QualifierName>
<QualifierName UI="Q000517" MajorTopicYN="Y">prevention & control</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008810" MajorTopicYN="N">Mice, Inbred C57BL</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010641" MajorTopicYN="N">Phenotype</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010962" MajorTopicYN="N">Plasmodium berghei</DescriptorName>
<QualifierName UI="Q000254" MajorTopicYN="Y">growth & development</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D046351" MajorTopicYN="N">Protoporphyria, Erythropoietic</DescriptorName>
<QualifierName UI="Q000201" MajorTopicYN="N">enzymology</QualifierName>
<QualifierName UI="Q000469" MajorTopicYN="N">parasitology</QualifierName>
<QualifierName UI="Q000517" MajorTopicYN="Y">prevention & control</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011524" MajorTopicYN="N">Protoporphyrins</DescriptorName>
<QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
</MeshHeading>
</MeshHeadingList>
<OtherID Source="NLM">PMC4296013</OtherID>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2014</Year>
<Month>11</Month>
<Day>22</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2014</Year>
<Month>11</Month>
<Day>22</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2015</Year>
<Month>3</Month>
<Day>13</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">25414439</ArticleId>
<ArticleId IdType="pii">blood-2014-04-567149</ArticleId>
<ArticleId IdType="doi">10.1182/blood-2014-04-567149</ArticleId>
<ArticleId IdType="pmc">PMC4296013</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/PubMed/Curation

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003031 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd -nk 003031 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Asie
   |area=    AustralieFrV1
   |flux=    PubMed
   |étape=   Curation
   |type=    RBID
   |clé=     pubmed:25414439
   |texte=   Red cells from ferrochelatase-deficient erythropoietic protoporphyria patients are resistant to growth of malarial parasites.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Curation/RBID.i   -Sk "pubmed:25414439" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd   \
       | NlmPubMed2Wicri -a AustralieFrV1

This area was generated with Dilib version V0.6.33.
Data generation: Tue Dec 5 10:43:12 2017. Site generation: Tue Mar 5 14:07:20 2024

	Serveur d'exploration sur les relations entre la France et l'Australie
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur les relations entre la France et l'Australie

Red cells from ferrochelatase-deficient erythropoietic protoporphyria patients are resistant to growth of malarial parasites.

Red cells from ferrochelatase-deficient erythropoietic protoporphyria patients are resistant to growth of malarial parasites.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Curation

No country items

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki